Biochem/physiol Actions

Primary Targetprotein carboxymethyltranferase

Secondary TargetFGF-2receptor tyrosine kinase activity

General description

A cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). Potently inhibits the protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also inhibits FGF-2 receptor tyrosine kinase activity as well as the proliferation of human astrocytes and glioma cells.

A naturally occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). A cell-permeable, reversible, and ATP-competitive inhibitor of protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also acts as an inhibitor of NGF-induced tyrosine phosphorylation in PC12 cells and blocks FGF-2 receptor tyrosine kinase in astrocytes and glioma cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Lee, S.H., and Cho, Y.D. 1998. Exp. Cell Res.240, 282.Smalheiser, N.R. 1998. Brain Res. Dev. Brain Res.51, 53.Joy, A., et al. 1997. Oncogene14, 171.Riscoe, M.K., et al. 1984. Biochem. Pharmacol.33, 3639.

Packaging

Packaged under inert gas

50 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.

Warning

Toxicity: Irritant (B)